May 06, 2008

Study: Bipolar Disorder Overdiagnosed

Over the last few years, I've read assertion upon assertion by psych researchers that bipolar disorder is underdiagnosed in adults and that it's vastly more prevalent among American adults than standard estimates suggest. That's usually followed by the assertion that people simply must be diagnosed or their time on Earth will be filled with unnecessary strife and torment. Pharma companies such as AstraZeneca even developed websites asserting that many cases of depression could actually be bipolar disorder and even had a website called isitreallydepression.com, which is now no longer active.

Now comes a small contrarian study in the psych world by Mark Zimmerman, a psych prof at Brown University, to be presented tomorrow at the American Psychiatric Association's convention. In a survey of 700 people, 145 indicated they'd been diagnosed with bipolar disorder yet Zimmerman found that only 43.4 percent of those diagnosed with bipolar disorder had been diagnosed by a doctor using the Structured Clinical Interview for DSM-IV. Although the doc doesn't come right out and say it in a press release, it's clear that he thinks some docs are diagnosing people far too casually (it's not clear from the press release if the other 46.6 percent of "bipolars" later checked out as bipolar on the SCID). Check out what he ascribes the cause to:

"'Clinicians are inclined to diagnose disorders that they feel more comfortable treating. We hypothesize that the increased availability of medications that have been approved for the treatment of bipolar disorder might be influencing clinicians who are unsure whether or not a patient has bipolar disorder or borderline personality disorder to err on the side of diagnosing the disorder that is medication responsive.' He continues, 'This bias is reinforced by the marketing message of pharmaceutical companies to physicians, which has emphasized the literature on the delayed and underrecognition of bipolar disorder, and may be sensitizing clinicians to avoid missing the diagnosis of bipolar disorder.'

"Zimmerman concludes, 'The results of this study suggest that bipolar disorder is being overdiagnosed and we recommend that clinicians use a standardized, validated method in diagnosing bipolar disorder.'"

Classically, bipolar disorder was estimated to affect about 1 percent of the adult US population but that estimate was bumped up to 2.2 percent by NIMH a couple of years ago, mostly to account for the prevalence of bipolar disorder type 2. But there have been numerous other researchers who've pressed for a prevalence of 4 percent, 5 percent and even as high as 11 percent.

Either way, Zimmerman is flat out accusing his colleagues of using their gut hunches with patients and of diagnosing based upon a person's reaction to medication, a very dangerous bit of backwards logic often employed in children (the Harvard bipolar child mafia have argued that since the kids they diagnose with bipolar disorder respond to antipsychotics and other meds then that proves they have child bipolar disorder). And, let's be clear that he's saying that doctors--you know, those rational, god-like creatures who do things based on Science--are being softened up by all those pharma ads saying bipolar is wildly underdiagnosed.

It will be interesting to see what kind of response this study gets.

Thoughts?

Posted by Philip Dawdy at May 6, 2008 07:40 AM
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Comments

Comments? If 'psych prof' means psychologist, then it all makes sense.

Posted by: row1 at May 6, 2008 08:02 AM

In some ways is it really the point to determine whether a disorder is underdiagnosed or overdiagnosed? Where does the diagnosis really get you anyway when you think about it? A diagnosis of bipolar 1, 2 or 3 -- what difference does it make? Of course it does make a difference as far as labeling the individual as a lifelong customer (woops, patient) but I mean in terms of treatment. We have treatments that were formerly for schizophrenia being used for bipolar and now we have those bipolar treatments being used for depression and even GAD. All this rumination over diagnosis might mean something if treatments really were different for each disorder and something/anything was demonstrated to be clinically effective long term (which it's not) but frankly in psychiatry it's all for one and one for all. By that I mean all meds for any diagnosis and any diagnosis for all meds. There needs to be a whole different way of looking at the symptoms and what they mean for that particular individual -- forget the diagnosis and probably the meds. Furthermore these disorders are on a spectrum and shouldn't really have separate names as if each one was some distinct "disease."

Posted by: Sara at May 6, 2008 08:12 AM

have argued that since the kids they diagnose with bipolar disorder respond to antipsychotics and other meds then that proves they have child bipolar disorder

who wouldn't "respond" to a sledgehammer over the head?

Posted by: Gianna at May 6, 2008 11:29 AM

Oh they haven't responded to antipsychotics; they were just given the standard "cocktail" that Biederman's Mafia dreamed up.

1. One or two mood stabilizers (Depakote & Lithobid were popular a decade ago while Biederman was researching Risperdal on children for ADHD in 1999)

2. One anti depressant (Zoloft was popular a decade ago, then Strattera)

3. One antipsychotic (Risperdal, Zyprexa were number one picks a decade ago)

Most doctors fell for that Biederman cocktail trap, and so did the wildly popular parent support group site CABF. They promoted that 3 med cocktail and still do, and Biederman's on their professional advisement board: BUT he refuses to do public interviews. I wonder why?

Think he will now? I would LOVE to know who spoke at a San Diego Conference in late-Summer, early -Fall 1999. Because, that is the conference the inpatient psych who treated my daughter and said, "just came back from and I've been told cases of OCD in children are actually Childhood Bipolar disorder". And that is how my daughter's journey began. With an immediate addition of Depakote, Risperdal and Zoloft. The Zyprexa replaced Risperdal due to side effects. In an 11 year old in 1999.

Looks like we have gotten no where fast alerting parents to this nightmare, and it's only to become worse as full blown anti psychotic use will prevail as the number one choice to drug these kids, and it will be for ADHD/Bipolar. Mark my words.

Posted by: Stephany at May 6, 2008 12:10 PM

I agree it's suspicious that this trend is coming at the same time as the rise of antipsychotics. Maybe psychiatrists felt like they had to be more careful when the only options were lithium or anticonvulsants, because those are pretty much useless for anything but bipolar disorder. But now that Seroquel and Risperdal can supposedly cure anything, everyone goes into the same antipsychotic soup, so what does it matter to them?

Posted by: Garth at May 6, 2008 02:00 PM

I just heard the tail end of a story on "All Things Considered" discussing this study this afternoon, ironic seeing as I got in and read your entry on the Infinite Mind.

Posted by: Sally at May 6, 2008 03:22 PM

In my private practice as a psychologist, I frequently find people misdiagnosed with Bipolar disorder. If someone has an anger problem, they often end up diagnosed as Bipolar. This happens frequently by family doctors and also psychiatrists. In my opinion, it's really often a matter of justifying the meds they want to prescribe (most often an antipsychotic). I'd say, anecdotally, that the level of overdiagnosis I see is pretty consistent with the studies results (50-60%). I do evaluations for people seeking disability based on mental illness diagnoses, so I frequently see people labeled as Bipolar. More often than not, the diagnosis is more consistent with a cluster B personality disorder (erratic, unstable, and hyperemotional personality traits). But once you diagnose someone as being Bipolar, you can pretty well throw any class of psychotropic medication at them that you want to.

Posted by: Parapraxis at May 6, 2008 06:51 PM

Yes, Parapraxis that's exactly what the psychiatrists told me 10 years ago about my daughter. "What's the difference what we call her the meds are all the same treatment".

That's BS! and THAT is why kids and adults are over dx and over-medicated.

Honest to God, get your head out of the DSM!

Posted by: Stephany at May 6, 2008 07:53 PM

This one-size-fits-all meds approach supports the notion that the Pharma industry has no idea what the underlying mechanism is for these drugs. What they seem to do is sedate, dull, or knockout, regardless of diagnosis.

If one of the pivotal symptoms for bipolar disorder is agnosia (lack of insight into the disease), for instance, then a successful medication "treatment" would effect a change in that symptom, leading to the patient's becoming aware of their disease, to the extent that they would see the usefulness of their medication. The volume of dropouts from bipolar medication suggests that this clarifying effect is not being achieved, and one wonders if most of those who remain on medication are simply being pressured into it because it "quiets" them.

The point I am making is that unlike diabetes, the docs have no idea what blood constituent to measure to see if their medication is successful. The only indicator they have is the patient's and family's self-report, and they have to discount the former because of the way they've defined the disorder (with agnosia).

I once took a tour of a Pharma company, and one of the most interesting parts was their "High-Throughput Analysis" section, where they had a robot machine testing thousands of samples of different reagents a minute to see which one got a reaction. This type of dartboard thinking is what is producing these medications, only now the patients are the targets.

Posted by: Susan at May 7, 2008 03:54 AM

Susan, I am among those people who do experience a "clarifying" effect from bipolar medications without feeling sedated or dulled - on the contrary - so I don't think you can paint the picture with such a broad brush. (I do not take antipsychotics, however.) The patients' subjective experience of mood is, by definition, the central characteristic of a mood disorder. So if doctors really are disregarding patients' self-reporting in diagnosing bipolar disorder, that points to a big deviation from the original concept and, in my opinion, another failure of the profession to set adequate guidelines for its members.

Posted by: Garth at May 7, 2008 08:53 AM

"doctors--you know, those rational, god-like creatures who do things based on Science--"

Yeap!
On Science, common sense, paying attention on the patients words, learning from their practice and experience, fighting hard to find the "origin" off the disease...
We all KNOW!

Posted by: Ana at May 9, 2008 04:39 PM

I haven't read all of the comments above, but, enough to finally read what I feared for at least 5 years now the over diagnosis of 'fad' mental illnesses. When my son was in the 5th grade, (1990), his teacher insisted that he had ADHD and insisted further that I take him to the doctors and have him evaluated. I did, the Doc said, "Oh, yes, he is classic ADHD, get him on meds so that he may fit in socially". I looked up the side effects to Ritalin and decided I would get a second opinion. In the meantime more and more kids were getting a diagnosis of ADHD. Families I met were wearing badges of adult ADD or ADHD. I had a bad feeling about this. When my son went on to the 6th grade, the PTA had a special parents conference about ADHD. I attended the seminar. A well spoken doctor led the meeting. He scared the hell out of me, really! I argued that I did not like the fact that so many school age children were being diagnosed left and right and parents were running to the pharmacy to fill the scripts for Ritalin. One parent said I was irresponsible and pretty much every one else chimed in. I told my sons 6th grade teacher I had no intentions of following the crowd on this one, because, what I was seeing were little zombies running around the neighborhood on Ritalin. I told him, "He is my son, I will tough this out with him." Surprisingly, he agreed. Then a few years later teenagers were being diagnosed with depression and parents were running to the pharmacy again for Prozac. Teenagers were committing suicided across this nation as a result. Then came the 21st century and Bipolar Disorder. Once again, people scrambled to the shrinks and the ever profited pharmacy's for more medicines. My Daughter was diagnosed with Bipolar Disorder 5 years ago. Two months after beginning Abilify, she got pregnant by her husband and so then she was off the meds until she gave birth to her son. She had a very emotional pregnancy and the minute she gave birth she was back on her meds. Okay, but then something happened when she was given anti-psychotics, she began to hear voices, terrible voices. I told her husband that I thought she was misdiagnosed and that some people actually present symptoms of a disorder if they are on the wrong meds. He said I was in LaLa land and an irresponsible parent (heard that before). All the confusion and overmeds were crippling for her and after 3 years of one cocktail after another from a psychiatrist that did not believe in therapists, she took a hand of Trazadone. She almost died.
I feel now, as I felt 18 years ago, that no doctor or psychiatrist should diagnose or treat with a medication a disorder that is hard to reach if the person is abusing substances of any kind; If a persons brain chemistry is alerted by weed, alcohol, cocaine or if that person, like my daughter, is in an abusive, mentally & emotionally, marriage, then the diagnosis will not be accurate...how could it?
My son has grown up into a fine man who is married has a son of his own and maintains a steady job and he does not suffer from any side of effects of a medicine that could have had ramifications on his heart or liver had I gone along with scare tactics of the 90's by doctors and communities alike about ADD or depression. My sweet daughter who has been to hell and back, is finally away from her abuser and she may have a long road back to health, but her new psychiatrist states that he can help her tone down the Bipolar, help her rid herself of her anxiety's and will most likely be removed from most of her cocktail of 4 meds, 3 being anti-psychotics.
Everyone should get more that one opinion on this new fad of a diagnosis, Bipolar, Borderline or Dissociative Disorder. I know some people need life saving meds, but, for your own sake, for the sake of your family and for gods sake, for the literal lives of the ones you love try to resist the pressure and be unafraid to question the "gods of medicine". A truly responsible doctor will listen and weigh the consequences with you.
Mary

Posted by: Mary Champion at May 12, 2008 11:39 AM

I think many family problems get masked by diagnosing the kid bipolar. Personal opinion.

JD Stottlemire, author
You me and Apollo: Hope Beyond Bipolar Disorder
http://www.youmeandapollo.com

Posted by: JD Stottlemire at July 1, 2008 03:41 PM
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